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宫颈细胞学筛查中不典型腺细胞的临床意义
祝建芳;吴荔香;修晓燕;詹燕美;
0
(福建省妇幼保健院)
摘要:
目的:探讨宫颈细胞学中不典型腺细胞(AGC)在筛查预防病变方面的临床价值。方法:对细胞学检查诊断为AGC的患者行宫颈活检+颈管搔刮、宫颈锥切、分段诊刮或子宫切除后的病理结果进行回顾性分析。结果:AGC检出率为0.6%(1016/157613)。1016例AGC中有效随访病例962例,阳性病例302例,阳性率31.4%,其中鳞状上皮病变113例(37.4%),腺上皮病变173例(57.3%),其他16例(5.3%)。370例≤40岁的患者中有效随访病例362例,阳性病例73例(20.2%),其中鳞状上皮病变45例(61.6%),腺上皮病变24例(32.9%),其他4例(5.5%);>40岁的646例患者中有效随访病例600例,阳性病例229例(38.2%),其中鳞状上皮病变68例(29.7%),腺上皮病变154例(67.2%),其他7例(3.1%)。AGC-倾向瘤变有效随访病例138例,阳性病例108例(阳性率78.3%),≤40岁和>40岁分别以HSIL病变和子宫内膜癌检出率最高。结论:AGC的检出率低,≤40岁病例以鳞状上皮病变为主,>40岁病例以腺上皮病变为主。AGC-倾向瘤变对宫颈及子宫内膜严重病变有非常重要的提示作用。
关键词:  宫颈细胞学  不典型腺细胞  临床意义
DOI:
基金项目:
Clinical Significance on Atypical Glandular Cells Incervical Cytology Screening Results
ZHU Jianfang;WU Lixiang;XIU Xiaoyan
(Fujian Provincial Maternity and Children Hospital)
Abstract:
Objective:To explore the clinical value of atypical glandular cells in screening and preventing disease.Methods:The pathologic results of Cervical biopsy+neck scratch scraping,cervical cone cutting,curettage or hysterectomy after the cytology diagnosis with AGC were retrospectively analyzed.Results:There were 962 effective follow-up cases in the 1016 cases of atypical glandular cell,positive cases 302 cases and the positive rate of31.4%.Among the 302 positive cases,there were 113 squamous epithelial lesions cases(37.4%),173 glandular epithelial lesions cases(57.3%) and 16 other lesions cases(5.3%).AGC detection rate was 0.6%(1016/157613).There were 362 effective follow-up cases in 370 cases of patients with the age≤40,including 73 positive cases(20.2%).The 73 positive cases included 45 cases Squamous epithelial lesions(61.6%),24 patients glandular epithelial lesions(32.9%) and 4 other cases(5.5%).There were 600 effective follow-up cases in646 cases of patients with the age>40,including 229 positive cases(38.2%).The 229 positive cases included 68 cases squamous epithelial lesions(29.7%),154 patients glandular epithelial lesions(67.2%) and 7 other cases(3.1%).There were 138 AGC-tendency neoplasia effective follow-up cases,which included 108 positive cases(positive rate 78.3%).The patients with 40 years old or less and>40 years old were the most frequently detected with HSIL pathological changes and endometrial carcinoma.Conclusions:AGC detection rate is low.The type of positive follow-up results are age-related,≤40 cases usually with squamous epithelial lesions and>40 cases usually with glandular epithelial lesions.AGC-tendency neoplasia has very important implication for cervical serious and endometrial disease
Key words:  Cervicalcytology  Atypicalglandularcells  Clinicalsignificance

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