| 摘要: |
| 目的:检测血管内皮生长因子(VEGF)和CD31在不同子宫内膜组织中的表达情况。方法:采用免疫组化方法检测VEGF、CD31在52例子宫内膜样腺癌组织、22例子宫内膜不典型增生组织及21例正常子宫内膜组织中的表达,对结果进行量化分析。结果:(1)VEGF在正常子宫内膜组织、不典型增生组织及子宫内膜样腺癌中表达的阳性率分别为23.8%、31.8%、65.4%;CD31在正常子宫内膜组织、不典型增生组织及子宫内膜样腺癌组织中标记的微血管密度(microvessel density,MVD)分别为23.6±11.7、31.5±17.7、51.9±21.1。VEGF的阳性表达及CD31-MVD(CD31标记的MVD)在子宫内膜样腺癌组织中明显高于不典型增生及正常子宫内膜组织(P<0.05)。(2)VEGF在子宫内膜样腺癌中的表达,与淋巴结转移有关(P<0.05)。CD31-MVD与肿瘤分期、浸润肌层深度、组织学类型有关(P<0.05)。(3)在子宫内膜样腺癌组织,VEGF表达与CD31-MVD无明显相关性(r=0.095,P=0.504)。结论:VEGF表达、CD31-MVD在子宫内膜样腺癌组织中增高,可能促进子宫内膜样腺癌的发生发展及转移浸润。 |
| 关键词: 子宫内膜样腺癌 血管生成 血管内皮生长因子 CD31 |
| DOI： |
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| 基金项目:国家自然科学基金(编号:81360388);广西自然科学基金(编号:2016 GXNSFAA380258) |
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| Expression and Clinical Significance of VEGF and CD31 in Eddometriod Carcinoma |
| XIA Xiuhong;FAN Jiangtao;LI Lili |
| (The First Affiliated Hospital of Guangxi Medical University) |
| Abstract: |
| Objective: To explore the expression of VEGF,CD31 in endometriod carcinoma.Methods: Expression levels of VEGF and CD31 in 52 cases of endometriod carcinoma,22 cases of atypical hyperplasia and 21 cases of normal endometrium tissues were analyzed by immunohistochemistry,and the blood vessels stained with CD31 were counted.Results:(1)The positive rate of VEGF expression in normal endometrium,atypical hyperplasia and endometriod carcinoma was 23. 8%,31. 8%,65. 4% respectively.The CD31-MVD was significantly different in normal endometrium,atypical hyperplasia and endometrial carcinoma,which were 23. 6 ± 11. 7,31. 5 ± 17. 7,51. 9 ± 21. 1 respectively.(2) The expression of VEGF was correlated with lymphatic metastasis( P < 0. 05). The CD31-MVD was correlated with tumor stage,myometrial invasion and histological grade( P<0. 05).(3)There was no correlation of VEGF and CD31 expression in endometriod carcinoma tissues( r = 0. 095,P = 0. 504). Conclusions: The over-expression of VEGF and CD31 may participate in angiogenesis of endometriod carcinoma. This research shows that they have clinical value as the tumor markers of endometriod carcinoma. |
| Key words: Endometriodcarcinoma Angiogenesis Vascularendothelialgrowthfactor CD31 |
