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不同方案GnRH-a降调节对轻中度子宫内膜异位症患者体外受精-胚胎移植结局的影响
王芳;柯雪;李敏;
0
(成都市妇女儿童中心医院)
摘要:
目的:探讨不同方案促性腺激素释放激素激动剂(GnRH-a)对轻中度子宫内膜异位症(EMT)患者行体外受精-胚胎移植(IVF-ET)的助孕结局的影响。方法:选择成都市妇女儿童中心医院生殖中心269个IVF助孕周期(175例患者)进行回顾性分析,按GnRH-a的不同方案进行分组:超长方案组75例共102个周期(长效GnRH-a 3.75 mg)、长效长方案组69例共87个周期(长效GnRH-a 1.875 mg)及短效长方案组31例共80个周期(GnRH-a 0.1 mg)。比较3种降调节方案的助孕情况及妊娠结局。结果:超长方案组中Gn用量及Gn天数均多于长效长方案组及短效长方案组,差异有统计学意义(P<0.05)。长效长方案组胚胎种植率、生化妊娠率及临床妊娠率高于超长方案组及短效长方案组,差异有统计学意义(P<0.05),超长方案组与短效方案组相比,差异无统计学意义(P>0.05)。结论:对于接受IVF助孕的轻中度EMT患者采用长效长方案降调节可能更有利于提高EMT不孕患者的临床妊娠率。
关键词:  促性腺激素释放激素激动剂  子宫内膜异位症  超长方案  长效长方案  短效长方案
DOI:
基金项目:
Effect of Different Dosage forms of Gonadotrophin-Releasing Hormone Agonist on In-Vitro Fertilization-Embryo Transfer in Patients with Mild Endometriosis
WANG Fang;KE Xue;LI Min
(Center of Reproductive Medicine,Chengdu Women’and Children’Hospital)
Abstract:
Objective:To investigate the effect of different dosage forms of gonadotropin-releasing hormone agonist(GnRH-a) on in vitro fertilization-embryo transfer(IVF-ET) in patients with mild endometriosis.Methods:Totally269 cycles(175 cases) of IVF-ET were included,which was divided into three groups:pro-long protocols(long acting 3.75 mg group,102 cycles),long protocols(long acting 1.875 mg group,87 cycles) and short protocols(short-acting 0.1 mg group,80 cycles).The clinical results were compared among groups.Results:The amount of gonadotropin(Gn) were significantly higher in pro-long protocol than the other ones.The implantation rate and clinical pregnancy rate were significantly higher in long acting 1.875 mg group than the other two protocols(P <0.05).Conclusions:Long protocol(long acting GnRH-a down-regulation,1.875 mg) may be more beneficial to improve the implantation rate and clinical pregnancy rate of in vitro fertilization-embryo transfer(IVF-ET) in patients with endometriosis.
Key words:  Gonadotropin-releasinghormoneagonist  Endometriosis  Pro-longprotocols  Longprotocols  Short-actingprotocols

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